Protein folding intermediates: native-state hydrogen exchange
نویسندگان
چکیده
منابع مشابه
Protein folding intermediates and pathways studied by hydrogen exchange.
In order to solve the immensely difficult protein-folding problem, it will be necessary to characterize the barriers that slow folding and the intermediate structures that promote it. Although protein-folding intermediates are not accessible to the usual structural studies, hydrogen exchange (HX) methods have been able to detect and characterize intermediates in both kinetic and equilibrium mod...
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ژورنال
عنوان ژورنال: Science
سال: 1995
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.7618079